CAS No:1190865-44-1
分子式:C8H2Cl2F4O
外观颜色:无色或淡黄色澄清液体
技术指标:98.5%
运输编号:-
包装:1/5/10/25千克/桶
供应能力:吨级
别名:1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone;2,2,2-Trifluoro-3',5'-dichloro-4'-fluoroacetophenone;Ethanone, 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-;1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one(Sarolaner intermediate）;1(3,5Dichloro4fluorophenyl)2,2,2trifluoroethanone,1 (3,5 Dichloro 4 fluorophenyl) 2,2,2 trifluoroethanone;Sealed in dry,Room Temperature;3',5'-DICHLORO-2,2,2,4'-TETRAFLUOROACETOPHENONE;1-(3,5-dichloroChemicalbook-4-fluorophenyl)-2,2,2-trifluoroethan-1-one(Sarolanerintermediate）; 1190865-44-1; 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone; 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one; DTXSID101204874; RefChem:422887; DTXCID101636293; 829-719-5; 939-298-0; 3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone; 1-(3,5-Dichloro-4-fluoro-phenyl)-2,2,2-trifluoroethanone; MFCD23382507; 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone; Ethanone, 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-; C8H2Cl2F4O; Sarolaner intermediate; orb1297912; orb1940156; SCHEMBL12097462; AKOS017344692; DS-9995; PB48056; SY253916; DB-190358; CS-0102824; T9728; F470774; 2,2,2-Trifluoro-3',5'-dichloro-4'-fluoroacetophenone
产品用途:1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone,1190865-44-1,1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone,3,5-Dichloro-4-fluoro-2,2,2-trifluoroacetophenone,Sarolaner intermediate,Isoxazoline veterinary drug intermediate,Antiparasitic API building block,Ectoparasiticide intermediate,Fluorinated aromatic ketone,Trifluoromethyl ketone building block,Agrochemical insecticide intermediate,Fine fluorinated chemical intermediate,High purity 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone 99.5%,CAS 1190865-44-1 supplier,Sarolaner intermediate manufacturer China,Suzhou Health Chemicals fluorinated chemicals,Sarolaner intermediate wholesale bulk export
1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone serves as an indispensable, ultra-pure polyhalogenated aromatic intermediate, benchmark veterinary pharmaceutical active pharmaceutical ingredient (API) building block, and versatile organofluorine synthon extensively utilized across modern companion animal ectoparasiticide manufacturing, novel agrochemical insecticide discovery, and specialty fine fluorochemical synthesis sectors. In animal health sciences and veterinary pharmaceutical process research, universally designated as 3,5-dichloro-4-fluoro-2,2,2-trifluoroacetophenone, it functions as the foundational raw material for the commercial total synthesis of blockbuster isoxazoline parasiticides, most notably sarolaner; its molecular architecture incorporates a precisely arranged 3,5-dichloro-4-fluorophenyl core functionalized with an electrophilic trifluoroacetyl handle, which facilitates high regioselectivity during condensation and oxime-mediated cyclization to construct the core active isoxazoline ring framework; the simultaneous presence of the perfluoromethyl group and dense halogenation on the aromatic core enhances lipophilicity, optimizes pharmacokinetic half-life, and ensures nanomolar allosteric binding potency against invertebrate gamma-aminobutyric acid (GABA) receptors and glutamate-gated chloride channels (GluCls) to rapidly eliminate fleas, ticks, and mites in companion animals without off-target mammalian neurotoxicity; this chemical architecture also mitigates metabolic clearance pathways, providing prolonged systemic circulation. In sustainable crop protection chemistry, it acts as an essential synthon for engineering next-generation agrochemical insecticides targeting resistant lepidopteran and acarine pests. Furthermore, in pharmaceutical lead discovery, specialty fluorinated liquid-crystalline precursors, and advanced functional coatings, chemical systems engineered from 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoro-Ethanone deliver exceptional chemical stability, reliable reaction kinetics, and broad multi-industry performance.
