N-Hydroxysuccinimide

Product Details

CAS No:6066-82-6

MF:C4H5NO3

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:N-HYDROXY-2,5-PYRROLIDINEDIONE;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINIMIDE;N-HYDROXYSUCCINIMIDE POLYMER-BOUND;NHS OR HONSU;HOSu~1-Hydroxy-2,5-pyrrolidinedione;N-Hydroxysuccinimide (HOSu);N-HYDROXYSUCCINAMIDE; N-Hydroxysuccinimide; 6066-82-6; 1-hydroxypyrrolidine-2,5-dione; 1-Hydroxysuccinimide; 1-Hydroxy-2,5-pyrrolidinedione; Hydroxysuccinimide; 2,5-Pyrrolidinedione, 1-hydroxy-; Succinimide, N-hydroxy-; MJE3791M4T; NSC-74335; DTXSID7064102; RefChem:830145; DTXCID7042855; 228-001-3; HOSu; N-hydroxy succinimide; MFCD00005516; N-hydroxysuccinimide (HOSu); NHS; Tofacitinib Impurity 121; N-hydroxysuccinimid; CCRIS 2604; N-hydroxy-succinimide; EINECS 228-001-3; NSC 74335; N-hydroxysuccinic acid imide; UNII-MJE3791M4T; 1-hydroxy-pyrrolidine-2,5-dione; N-hydroxysucinimide; N-hyroxysuccinimide; N-Hydroxysuccinimde; N-Hydroxylsuccinimide; n-hydroxysuccin imide; 1-Hydroxy-2,5-pyrrolidinedione; NHS; HOSu.; 2, 1-hydroxy-; N-hy dr oxy succinimide; N-Hydroxysuccinimide NHS; n-hydroxysuccinimide (nhs); SCHEMBL1123; Sigma 130672; N-Hydroxysuccinimide, 98%; NCIOpen2_000470; SCHEMBL44131; HYDROXYSUCCINIMIDE, N-; SCHEMBL785147; hydroxy-pyrrolidine-2,5-dione; CHEMBL403753; n-hydroxypyrrolidine-2,5-dione; orb2565681; SCHEMBL4698157; N-HYDROXYSUCCINIMIDE [MI]; HY-Y0623; NSC74335; STR01867; STL183832; AKOS000121489; AB00437; CS-W008598; FH02165; N-HYDROXY-2,5-DIOXOPYRROLIDINE; PS-4557; AC-10509; AC-15786; BP-13159; SY001334; DB-298765; B0249; H0623; NS00022482; EN300-17439; N-Hydroxysuccinimide, purum, >=97.0% (T); T87003; F005022; Q408833; Z56933833; F0001-1588; InChI=1/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H

Product application:N-Hydroxysuccinimide,6066-82-6,NHS,HOSu,1-Hydroxypyrrolidine-2,5-dione,Succinimide-N-oxide,Peptide coupling reagent,Active ester forming agent,EDC NHS coupling additive,Carbodiimide crosslinking enhancer,ADC drug crosslinker,Bioconjugation reagent,Protein crosslinking agent,Biotinylation activation reagent,In vitro diagnostic IVD magnetic bead coupling,NHS ester precursor,Biochemical labeling reagent,Oligonucleotide synthesis additive,Amine carboxyl crosslinker,High purity N-Hydroxysuccinimide 99.5%,N-Hydroxysuccinimide manufacturer China,CAS 6066-82-6 supplier,Suzhou Health Chemicals biochemical reagents,NHS wholesale bulk export

 

N-Hydroxysuccinimide serves as an indispensable, ultra-pure biochemical activation reagent, benchmark peptide-coupling additive, and versatile bioconjugation synthon extensively utilized across therapeutic peptide manufacturing, antibody-drug conjugates (ADCs), in vitro diagnostic (IVD) immunochemistry, biomedical hydrogel engineering, and fine organic synthesis sectors. In commercial therapeutic peptide chemistry and solid-phase peptide synthesis (SPPS), universally designated as NHS or HOSu, it represents the foundational carboxyl-activating auxiliary used in conjunction with carbodiimide coupling partners, such as EDC and DCC; by reacting with in-situ generated O-acylisoureas, it cleanly forms stable yet amine-reactive NHS-active esters that prevent non-productive N-acylurea rearrangement pathways while drastically suppressing epimerization and racemization at terminal alpha-carbon stereocenters, delivering high-fidelity assembly of complex therapeutic peptides, glucagon-like peptide-1 (GLP-1) analogues, and cyclic therapeutics. In targeted biopharmaceuticals and antibody-drug conjugate (ADC) platform engineering, NHS ester chemistry provides the gold-standard methodology for functionalizing chemical linkers to achieve stable, chemoselective acylation of solvent-exposed lysine epsilon-amines on monoclonal antibodies, allowing the precise, reproducible attachment of antineoplastic payloads and specialized fluorophores under physiological conditions. In clinical molecular diagnostics and in vitro diagnostic assay manufacturing, it functions as an essential surface-activation agent for covalently coupling antibodies, oligonucleotides, and enzymes onto carboxyl-functionalized paramagnetic beads, ELISA plates, and lateral flow colloidal matrices, ensuring elevated analytical sensitivity, minimal non-specific background binding, and prolonged shelf-life stability. In biomaterials engineering, it activates polysaccharide and protein backbones, including hyaluronic acid, collagen, and chitosan, to yield biodegradable surgical sealants, crosslinked hemostatic sponges, and regenerative tissue engineering matrices. In nanoscale bioelectronics and surface modification, it enables the covalent anchoring of biorecognition probes onto functionalized self-assembled monolayers (SAMs) on surface plasmon resonance (SPR) biochips and silicon sensors. Furthermore, in antifouling ultrafiltration membranes, polymeric specialty crosslinkers, and anti-corrosive chemisorption coatings for oil and natural gas infrastructure, chemical transformations mediated by N-Hydroxysuccinimide deliver extraordinary chemoselective control, mild reaction kinetics, and broad multi-industry performance.