Polidronium Chloride; Polyquaternium-1; Polyquad-1; PQ-1

Product Details

CAS No:75345-27-6

MF:-

Appearance:cream to light-yellow or amber to dark brown solid

Specification:≥95.0%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:kgs

Product application:Polidronium Chloride, Polyquaternium-1, Polyquad, PQ-1, CAS 75345-27-6, Polyquaternium-1 solution, Antimicrobial agent for contact lens care, Preservative for ophthalmic solutions, Cationic polymer antibacterial, Contact lens disinfecting solution ingredient, Low toxicity preservative, PQ-1 manufacturer, High purity Polidronium Chloride.

Synonyms:Polidronium Chloride; Polyquaternium-1; PQ-1; D01912; Onamer M; Onyxsperse 12S; Polidronium chloride; Polyquad; Polyquat 1; Polyquaternium 1; [(E)-4-[dimethyl-[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azaniumyl]but-2-enyl]-tris(2-hydroxyethyl)azanium trichloride; [(E)-4-[dimethyl-[(E)-4-[tris(2-hydroxyethyl)ammonio]but-2-enyl]ammonio]but-2-enyl]-tris(2-hydroxyethyl)ammonium trichloride; 75345-27-6; D01912; Polidronium chloride; Polidronium chloride (JAN); alpha-((E)-4-(Tris(2-hydroxyethyl)ammonio)-2-butenyl-omega-(tris(2-hydroxyethyl)ammonio)poly((dimethyliminio)((E)-2-butenylene)chloride)dichloride; Polidronium chloride [BAN:INN]; Polidronium Chloride; 75345-27-6; Polyquaternium 1; 6716Z5YR3G; Onamer M; Polyquad; Onyxsperse 125; POLIDRONIUM CHLORIDE (II); UNII-6716Z5YR3G; chlorure de polidronium; cloruro de polidronio; polidroninii chloridum; Polyquaternium 1,DTXCID301511398; DTXSID701027149; 688-145-1; Polidronium chloride; 75345-27-6; dimethyl-bis[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azanium;trichloride; SCHEMBL329104; CHEBI:32025; Polidronium chloride (JAN/INN); OTIWYSKRSMXGNK-VHJGTCNUSA-K; [(E)-4-[dimethyl-[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azaniumyl]but-2-enyl]-tris(2-hydroxyethyl)azanium trichloride; AS-83276; FP163582; DB-248423; NS00013989; D01912; A937800; Q1493560,557.000,C22H48Cl3N3O6,

 

规格 / Specification

项目 / Item	标准 / Standards
外观 / Appearance	淡黄色或深褐色固体 / Cream to light yellow or amber to dark brown solid
气味/ Odor	无刺激 / Without stimulation
纯度 / Purity	≥95%

 

应用 / Applications

抑菌剂 / antibacterial preservative

 

1: Contact Lens Solutions: A common preservative in contact lens storage and rinsing solutions to maintain sterility. For monthly or annual contact lenses, the proteins, enzymes and oils in the tear film accumulate on the lenses over time. Excessive accumulation will damage the quality of the tear film between the lens and the cornea, causing dry eyes, congestion and discomfort. Therefore, we need to remove foreign matter from the lenses regularly. The role of the care solution is to sterilize and dissolve the proteins on the lenses. Polyquaternium-1 (Polyquad-1; PQ-1; CAS# 75345-27-6) and Myristamidopropyl Dimethylamine(CAS# 75345-27-6) are used in the care solution as new and milder bactericides.

 

2: Eye Drops: Used as a bacteriostatic agent in multi-dose eye drops for conditions like glaucoma and artificial tears. It helps prevent microbial contamination after the bottle is opened. It is considered less toxic and causes less ocular irritation compared to some traditional preservatives like benzalkonium chloride (BAK).

 

3: Cosmetics and Personal Care Products:

3.1: Preservative: Its antimicrobial properties help prevent spoilage and ensure product safety.

3.2: Conditioning Agent: Can enhance hair manageability and softness in shampoos and conditioners.

3.3: Film-Forming Agent: May provide a protective layer on the skin or hair.

3.4: Stabilizer: Can improve the stability of emulsions in creams and lotions.

 

4: Pharmaceutical Formulations: Used as an excipient in some drug formulations to enhance solubility and bioavailability of active ingredients and as a stabilizing agent in drug delivery systems.

 

5: Medical Devices: Can be used as a surface protection antimicrobial for medical devices.

 

Politronium Chloride is a highly hydrophilic cationic polymer, chemically classified as a polyquaternary ammonium salt. Due to its large molecular weight, Politronium Chloride possesses unique biocompatibility. It effectively adsorbs onto the surface of microorganisms and disrupts their cell membranes, thus achieving a highly effective bactericidal effect. However, its large molecular structure prevents it from penetrating corneal epithelial cells or entering the interior of contact lens materials, making it extremely gentle on human eye tissue. It is currently recognized internationally as one of the safest ophthalmic antiseptics and bactericides.

 

1: Politronium Chloride is used as a core bactericide in the contact lens care solution industry. It exhibits strong killing effects against various common pathogenic microorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Due to its large molecular characteristics, it is not absorbed by soft contact lenses and silicone hydrogel lenses, thus avoiding eye allergies or chemical burns caused by bactericide accumulation, greatly improving wearer comfort.

2. Politronium Chloride is widely used as a preservative in ophthalmic pharmaceuticals, specifically in eye drops and artificial tears. Compared to traditional benzalkonium chloride, politronium Chloride has extremely low toxicity and does not damage corneal epithelial cells. Even long-term use of eye drops containing this ingredient by patients with dry eye syndrome can maintain good ocular surface health, making it the preferred preservative system for high-end ophthalmic prescription drugs.

3. Politronium Chloride is used as a mild antibacterial and conditioning agent in the personal care and cosmetics industry. It has good cationic activity, adsorbing onto hair or skin surfaces to provide excellent antistatic effects and a silky feel. In high-end shampoos, conditioners, and facial cleansers for sensitive skin, it both assists in system preservation and enhances the product's tactile properties.

4. Politronium Chloride is used as a surface disinfectant in the field of biochemical medical device cleaning. It can be used for surface disinfection of precision medical optical instruments. Its non-volatile and stable properties ensure that it can effectively inhibit the formation of bacterial biofilms during the cleaning process without causing corrosive damage to the coating on the instrument surface.

 

包装 / Packing

1g-10kgs/bottle

 

运输编号 / UN number

普通化学品 / Not dangerous goods

 

储存条件 / Store at

密封保存于阴凉干燥处，避光避热 / Sealed storage in a cool and dry place, avoid light and heat.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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