Fmoc-L-Aspartic acid beta-tert-butyl ester

Product Details

CAS No:71989-14-5

MF:C23H25NO6

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:Fmoc-(tBu)Asp-OH;cas:71989-14-5;Fmoc-L-aspartic acid β-tert-butyl ester≥ 99.7% (HPLC, Chiral purity);N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID BETA-T-BUTYL ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA-T-BUTYL ESTER;N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID BETA-T-BUTYL ESTER;N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER; EINECS 276-251-7; 4-tert-Butyl hydrogen N-((9H-fluoren-9-ylmethoxy)carbonyl)-L-aspartate; 4-tert-butyl hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate; RefChem:296355; 276-251-7; 71989-14-5; Fmoc-DL-Asp(Otbu)-OH; 205812-14-2; 4-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-oxobutanoic acid; Fmoc-D-Asp(OBut)-OH; Fmoc-L-aspartic acid b-tert-butyl ester; 1217468-27-3; 5BR9VNF2HW; SCHEMBL3722284; SCHEMBL29400614; SCHEMBL30261869; FDD-1806-PI; AKOS016016011; 2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid; PD196876; EN300-151840; N-Alpha-Fmoc-D-aspartic acid beta-t-butyl ester; N-Alpha-Fmoc-L-aspartic acid beta-t-butyl ester; 4-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid; N-alpha-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid beta-t-butyl ester; 4-(1,1-Dimethylethyl) hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]aspartate; Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester

Product application:Fmoc-L-Aspartic acid beta-tert-butyl ester,71989-14-5,Fmoc-L-Asp(OtBu)-OH,Fmoc-Asp(OtBu)-OH,N-alpha-Fmoc-L-aspartic acid beta-tert-butyl ester,Fmoc protected amino acid,Solid phase peptide synthesis reagent,SPPS building block,Peptide active pharmaceutical ingredient intermediate,GLP-1 peptide synthesis raw material,Peptide drug conjugate building block,Macrocyclic peptide synthesis monomer,Chiral peptide reagent,Targeted peptide oncology intermediate,Peptidomimetic building block,High purity Fmoc amino acid 99.5%,Research biochemical CAS 71989-14-5,Custom peptide synthesis building block,Fmoc-L-Asp(OtBu)-OH manufacturer China,CAS 71989-14-5 supplier,Suzhou Health Chemicals peptide reagents,Fmoc-Asp(OtBu)-OH wholesale bulk export

 

Fmoc-L-Aspartic acid beta-tert-butyl ester serves as an indispensable, high-purity orthogonally protected chiral amino acid monomer and foundational building block extensively utilized across the peptide therapeutics manufacturing, solid-phase peptide synthesis (SPPS), medicinal chemistry, and bioconjugation sectors. In commercial peptide active pharmaceutical ingredient (API) production and automated peptide synthesizers, its base-labile N-alpha-Fmoc protecting group allows rapid, quantitative deprotection using piperidine, while the acid-labile beta-tert-butyl ester (OtBu) provides robust steric and electronic shielding to the beta-carboxylic moiety throughout iterative coupling cycles; this orthogonal protection strategy effectively suppresses deleterious side reactions, including aspartimide rearrangement and stereochemical racemization, ensuring high crude peptide purity and seamless global deprotection during final trifluoroacetic acid cleavage. Consequently, it is globally applied in the industrial-scale synthesis of metabolic GLP-1 receptor agonists, peptide hormone analogues, macrocyclic antimicrobial peptides, and targeted peptide-drug conjugates (PDCs). In drug discovery and molecular design, this building block is widely employed to construct aspartate-containing peptidomimetic motifs, protease inhibitors, and receptor-targeting diagnostic probes. Furthermore, in academic chemical biology and protein engineering, Fmoc-L-Asp(OtBu)-OH remains a vital standard synthetic reagent for preparing post-translationally modified peptides, structural chemical biology tools, and functional biomaterial hydrogels.