1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

Product Details

CAS No:1125812-58-9

MF:C9H3ClF6O

Appearance:colorless or light-yellow transparent liquid

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone;3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone;2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone;3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone;Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-;1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one(Afoxolaner intermediate）;1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone ISO 9001：2015 REACH;afoxolaner-002; 1125812-58-9; 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone; 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanone; EC 808-269-3; RefChem:74296; 808-269-3; 1-[3-CHLORO-5-TRIFLUOROMETHYLPHENYL]-2,2,2-TRIFLUOROETHANONE; MFCD19440960; 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-ethanone; 3'-Chloro-5'-trifluoromethyl-2,2,2-trifluoroacetophenone; DTXSID40696901; AKOS016012362; 1-(3-CHLORO-5-TRIFLUOROMETHYLPHENYL)-2,2,2-TRIFLUOROETHANONE; 1-[3-Chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one; EN300-1938991; 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one; 1-[3-Chloro-5-(; SCHEMBL980627; WLZ3525; AS-75830; SY259231; DB-328490; CS-0186238; NS00004798; F320632; 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethano

Product application:1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone,1125812-58-9,1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one,3'-Chloro-5'-trifluoromethyl-2,2,2-trifluoroacetophenone,Afoxolaner intermediate,Afoxolaner-002,Afoxolaner Impurity 6,Isoxazoline veterinary intermediate,Antiparasitic API building block,Ectoparasiticide intermediate,Fluorinated aromatic ketone,Trifluoromethyl ketone building block,Agrochemical insecticide intermediate,Fine fluorinated chemical intermediate,High purity 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone 99.5%,CAS 1125812-58-9 supplier,Afoxolaner intermediate manufacturer China,Suzhou Health Chemicals fluorinated chemicals,Afoxolaner intermediate wholesale bulk export

 

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone serves as an indispensable, ultra-pure polyhalogenated aromatic intermediate, benchmark veterinary pharmaceutical active pharmaceutical ingredient building block, and versatile organofluorine synthon extensively utilized across modern companion animal ectoparasiticide manufacturing, novel agrochemical insecticide discovery, and specialty fine fluorochemical synthesis sectors. In animal health sciences and veterinary pharmaceutical process research, universally designated as 3'-chloro-5'-trifluoromethyl-2,2,2-trifluoroacetophenone, it functions as the foundational raw material for the commercial total synthesis of blockbuster isoxazoline parasiticides, most notably afoxolaner; its molecular architecture incorporates a precisely functionalized 3-chloro-5-trifluoromethylphenyl core bearing an electrophilic trifluoroacetyl moiety, which facilitates high regioselectivity during condensation and oxime-mediated cyclization to construct the core active isoxazoline ring framework; the simultaneous presence of twin trifluoromethyl groups and aromatic halogenation enhances lipophilicity, optimizes pharmacokinetic half-life, and ensures nanomolar allosteric binding potency against invertebrate gamma-aminobutyric acid receptors and glutamate-gated chloride channels to rapidly eliminate fleas, ticks, and mites in companion animals without off-target mammalian neurotoxicity; this chemical architecture also mitigates metabolic clearance pathways, providing prolonged systemic circulation. In sustainable crop protection chemistry, it acts as an essential synthon for engineering next-generation agrochemical insecticides targeting resistant lepidopteran and acarine pests. Furthermore, in pharmaceutical lead discovery, specialty fluorinated liquid-crystalline precursors, and advanced functional coatings, chemical systems engineered from 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone deliver exceptional chemical stability, reliable reaction kinetics, and broad multi-industry performance.