Thiothiamine

Product Details

CAS No:299-35-4

MF:C12H16N4OS2

Appearance:white or light-yellow crystalline powder

Specification:98.0%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:MT

Synonyms:3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-2(3H)-Thiazolethione;sulbone;3-(4-Amino-2-methyl-5-pyrimidinylmethyl)-5-(2-hydroxyethyl)-4-methyl-4-thiazoline-2-thione;3-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-5-(β-hydroxyethyl)-4-methyl-4-thiazoline-2-thione;Solbone;Thiothlamine;Thiamin-2-thione;Thiamin EP Impurity E

Product application:Thiothiamine,299-35-4,Thioxothiamine,Thiamin-2-thione,3-(4-Amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazole-2(3H)-thione,Thiamine impurity A,Vitamin B1 intermediate,Thiamine hydrochloride precursor,Thiamine mononitrate raw material,Fursultiamine intermediate,Benfotiamine building block,Pharmaceutical grade Thiothiamine,Antineuritic vitamin intermediate,Lipophilic thiamine derivative raw material,Feed additive vitamin B1 precursor,Biochemical reagent,Sulfur heterocyclic intermediate,Fine organic chemical intermediate,High purity Thiothiamine 99%,Thiothiamine manufacturer China,CAS 299-35-4 supplier,Suzhou Health Chemicals specialty chemicals,Thiothiamine wholesale bulk export

 

Thiothiamine serves as an indispensable, high-purity heterocyclic building block, vital pharmaceutical active ingredient precursor, and versatile bio-organic intermediate extensively utilized across vitamin manufacturing, human dietary supplements, veterinary animal nutrition, metabolic biochemistry, and specialty chemical synthesis sectors. In commercial pharmaceutical manufacturing and industrial vitamin synthesis, universally designated as Thiamin-2-thione or Thiamine Impurity A, its unique molecular architecture seamlessly bridges a functionalized aminopyrimidine ring with a substituted thiazole-2-thione nucleus; it represents the foundational, irreplaceable penultimate intermediate for the commercial-scale synthesis of Vitamin B1 (Thiamine Hydrochloride and Thiamine Mononitrate) through selective catalytic oxidative desulfurization using hydrogen peroxide or nitric acid, supplying global production of essential clinical therapeutics for beriberi, peripheral neuropathy, and metabolic exhaustion. Furthermore, this synthon serves as the key chemical platform for synthesizing advanced lipophilic, high-bioavailability thiamine prodrugs, including Benfotiamine, Fursultiamine, and Sulbutiamine, which overcome the intestinal rate-limiting transport barrier of conventional thiamine to achieve sustained plasma and intracellular concentrations indicated for diabetic neuropathy, Alzheimer-type cognitive decline, and neurodegenerative disorders. In livestock husbandry and aquaculture nutrition, it functions as an essential synthetic precursor for specialized feed-grade thiamine formulations designed to prevent avian polyneuritis, bovine cerebrocortical necrosis, and crustacean metabolic stress syndromes. In enzymatic research and bioconjugate chemistry, it acts as a molecular probe for investigating thiamine pyrophosphate-dependent decarboxylases and transketolases. Furthermore, in agricultural plant growth stimulants, specialized sulfur-containing functional surfactants, polymer anti-aging additives, and antimicrobial pipeline treatments for petroleum and natural gas infrastructure, chemical architectures derived from Thiothiamine deliver outstanding synthetic versatility, heterocyclic stability, and broad multi-industry performance.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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