4-Chloro-6-ethyl-5-fluoropyrimidine

Product Details

CAS No:137234-74-3

MF:C6H6ClFN2

Appearance:colorless or light-yellow transparent liquid

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:4-chloro-6-ethyl-5-fluoropyiMidine;4-CHLORO-6-ETHYL-5-FLUOROPYRIMIDINE;4-chloro-6-ethyl-5-flouropyrimidine;6-CHLORO-4-ETHYL-5-FLUORO-1,6-DIHYDROPYRIMIDINE;4-Chloro-6-ethyl-5-fluoropyrimidine（Voriconazole）;Voriconazole Impurity 26;4-Chloro-5-fluoro-6-ethylpyriMidine;PyriMidine, 4-chloro-6-ethyl-5-fluoro-; 4-Chloro-6-ethyl-5-fluoropyrimidine; 137234-74-3; DTXSID30587753; EC 604-010-1; RefChem:98483; DTXCID20538517; 604-010-1; PYRIMIDINE, 4-CHLORO-6-ETHYL-5-FLUORO-; MFCD07782087; 4-Chloro-6-ethyl-5-fluoro-pyrimidine; SCHEMBL372414; CS-B1291; Voriconazole Impurity 16; BCP04247; N88Y96VTY2; 4-chloro-6-ethyl-5-fluoro pyri; AKOS005063655; AC-4747; PB10473; AS-15052; SY011522; DB-042382; NS00004637; EN300-102307; 4-Chloro-6-ethyl-5-fluoropyrimidine, AldrichCPR; F078990; F0001-0470; Z1198174780

Product application:4-Chloro-6-ethyl-5-fluoropyrimidine,137234-74-3,4-Ethyl-5-fluoro-6-chloropyrimidine,6-Chloro-4-ethyl-5-fluoropyrimidine,Voriconazole intermediate,Voriconazole side chain raw material,Voriconazole building block,Antifungal API intermediate,Broad-spectrum antifungal precursor,Invasive aspergillosis therapeutic intermediate,Fluorinated pyrimidine building block,Halogenated pyrimidine derivative,Agricultural fungicide intermediate,Fluorinated agrochemical raw material,Crop protection chemical building block,Specialty biocide precursor,Industrial antimildew agent raw material,Fine chemical intermediate,High purity 4-Chloro-6-ethyl-5-fluoropyrimidine 99%,4-Chloro-6-ethyl-5-fluoropyrimidine manufacturer China,CAS 137234-74-3 supplier,Suzhou Health Chemicals fluorochemicals,Voriconazole intermediate wholesale bulk export

 

4-Chloro-6-ethyl-5-fluoropyrimidine serves as an indispensable, high-purity fluorinated heterocyclic building block, vital active pharmaceutical ingredient (API) intermediate, and versatile reactive synthon extensively utilized across antifungal therapeutics, green crop protection chemistry, industrial antimicrobial engineering, and fine organic synthesis sectors. In commercial pharmaceutical manufacturing and clinical medicinal chemistry, functioning as the foundational fluorinated pyrimidine pharmacophore integrating reactive 4-chloro, 5-fluoro, and 6-ethyl substituents, it is the premier, irreplaceable starting raw material for the industrial stereoselective synthesis of Voriconazole, a blockbuster second-generation triazole broad-spectrum antifungal agent; Voriconazole exerts targeted fungicidal activity by selectively inhibiting fungal cytochrome P450-dependent 14alpha-lanosterol demethylase (CYP51), disrupting ergosterol membrane synthesis to serve as the clinical frontline standard-of-care for managing life-threatening invasive aspergillosis, refractory candidemia, scedosporiosis, and fusariosis. In sustainable agrochemical engineering and crop protection, this fluorinated pyrimidine heterocyclic scaffold provides superior systemic translocation and metabolic stability, making it an essential precursor for developing novel fluorinated agricultural fungicides and protective agents that control powdery mildew, sheath blight, and botrytis across grain and horticultural crops. In industrial materials preservation and antimildew technologies, its functionalized derivatives are formulated into high-efficiency wood preservatives, anti-fungal furniture coatings, leather finishing mildew inhibitors, functional textile antimicrobial treatments, and exterior architectural antimildew paints. Furthermore, in functional structural adhesives, specialty graphic printing inks, and biocidal water-treatment formulations for oilfield drilling and cooling systems, chemical compounds derived from 4-Chloro-6-ethyl-5-fluoropyrimidine deliver outstanding broad-spectrum antimicrobial efficacy, photo-stability, and multi-industry durability.