1,2-Ethanedithiol

Product Details

CAS No:540-63-6

MF:C2H6S2

Appearance:colorless or light-yellow transparent liquid

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:MT

Synonyms:1,2- B twoMercaptan;Ethylene dithioglycol;Ethylene glycol, dithio-;ethylenedithioglycol;ethylhydropersulfide;s-Ethylene dimercaptan;s-ethylenedimercaptan;DITHIOETHYLENE GLYCOL; 1,2-ETHANEDITHIOL; 540-63-6; Ethane-1,2-dithiol; 1,2-Dimercaptoethane; Dithioglycol; Ethylene mercaptan; Ethylenedithiol; Ethylene dithioglycol; Ethylene dimercaptan; Ethylenedimercaptan; Dithioethyleneglycol; S-Ethylene dimercaptan; Ethylene glycol, dithio-; 1,2-Dithiol ethane; Ethyl hydropersulfide; FEMA No. 3484; Dithioethylene glycol; 92T634FLAR; NSC-60481; DTXSID9052187; RefChem:72084; DTXCID9030757; 208-752-3; ethandithiol; 1,2-Ethanethiol; Ethane-1.2-dithiol; MFCD00004892; NSC 60481; 1,2-Dithiolethane; HSDB 2828; Ethanedithiol, 1,2-; EINECS 208-752-3; BRN 0505946; UNII-92T634FLAR; AI3-28942; 1,2-ethandithiol; 6LN; Mesna Impurity 13; ethane 1,2-dithiol; ethane-1 2-dithiol; 1,2-Ethane dithiol; a-Ethylene dimercaptan; Dithio-Ethylene glycol; ethane-1, 2-dithiol; ethane-1,2,-dithiol; alpha-Ethylene dimercaptan; WLN: SH2SH; 2-MERCAPTOETHANETHIOL; SCHEMBL63132; SCHEMBL64333; 4-01-00-02450 (Beilstein Handbook Reference); SCHEMBL810999; SCHEMBL5888410; FEMA 3484; 1,2-ETHANEDITHIOL [MI]; 1,2-ETHANEDITHIOL [FHFI]; 1,2-ETHANEDITHIOL [HSDB]; NSC60481; 1,2-Ethanedithiol Ethylene mercaptan; AKOS000120425; 1,2-Ethanedithiol, analytical standard; EBC-627208; FE00131; 1,2-Ethanedithiol, >=98.0% (GC); BP-31021; BP-31166; DB-003156; NS00022338; 1,2-Ethanedithiol, technical grade, >=90%; EN300-20350; D78347; M03555; InChI=1/C2H6S2/c3-1-2-4/h3-4H,1-2H; Q2738870; F0001-1413; 27515-15-7

Product application:1,2-Ethanedithiol,540-63-6,EDT,Ethanedithiol,Ethylene mercaptan,1,2-Dimercaptoethane,Peptide synthesis grade EDT,Solid phase peptide synthesis scavenger,SPPS cleavage cocktail additive,Carbocation scavenger,Carbonyl protecting reagent,Thioacetalization reagent,1,3-Dithiolane precursor,Pharmaceutical intermediate,Bidentate dithiol ligand,Organosulfur building block,Low moisture EDT,Ultra-pure 1,2-Ethanedithiol 99.5%,CAS 540-63-6 supplier,1,2-Ethanedithiol manufacturer China,Suzhou Health Chemicals specialty chemicals,1,2-Ethanedithiol wholesale bulk export

 

1,2-Ethanedithiol finds widespread and practical utility across commercial therapeutic peptide manufacturing, solid-phase peptide synthesis (SPPS) cleavage processing, selective organic carbonyl protection and deprotection, organometallic coordination chemistry, advanced optoelectronic materials, and fine pharmaceutical synthesis sectors. In peptide chemical biology and active pharmaceutical ingredient synthesis, universally designated as EDT, it serves as an indispensable carbocation scavenger in trifluoroacetic acid (TFA) cleavage cocktails; during the global acidolytic cleavage of side-chain protecting groups and simultaneous release of synthesized peptide chains from solid polymer resins, EDT rapidly and irreversibly quenches highly reactive tert-butyl, trityl, and sulfonyl carbocations, preventing the alkylation of sensitive tryptophan, tyrosine, and cysteine residues while suppressing the sulfoxide oxidation of methionine, thereby dramatically improving crude peptide purities and overall synthetic yields for therapeutic peptides like semaglutide and octreotide; in general synthetic organic chemistry, it acts as a standard bifunctional dithiol reagent for carbonyl protection, reacting smoothly with aldehydes and ketones under Lewis acid catalysis to form 1,3-dithiolanes; these cyclic thioacetal rings exhibit exceptional thermodynamic stability against aggressive acids, strong bases, and nucleophilic hydrides, and they can subsequently be desulfurized via Raney nickel hydrogenation into methylene hydrocarbons or cleavaged back into parent carbonyls using thiophilic heavy metal salts; in bioinorganic chemistry and organometallic catalysis, its vicinal dithiols operate as robust bidentate chelating ligands with transition metals such as molybdenum and iron, enabling the biomimetic modeling of natural hydrogenase and nitrogenase catalytic cores; furthermore, in semiconductor surface chemistry, thin-film interface functionalization, and functional crosslinking networks for heavy metal scavenging, 1,2-Ethanedithiol functions as a critical organosulfur building block delivering exceptional reactivity and reproducible chemical processing performance across industries.