G418 sulfate

Product Details

CAS No:108321-42-2

MF:C20H40N4O10.2(H2SO4)

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:KGS

Synonyms:TRYPSIN INHIBITOR SOYBEAN REAGENT GRADE;G-418 disulfate,Geneticin;Geneticin Disulfate (G418), Antibiotic for Culture Media Use Only;Geneticin disulfate saltPotency ≥ 700 ug/mg (anhydrous basis);Antibiotic G418Geneticin®2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuric acid;G 418 Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested;D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (1:2); (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; (2S,3S,4S,5S)-2-((1S,2S,3R,4S,6R)-4,6-diamino-3-((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; RefChem:398888; 600-864-4; 108321-42-2; G 418 disulfate salt; G418 Disulfate; G-418.Sulfate Solid; Geneticin disulfate; M01801; 2-[4,6-Diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid; Geneticin disulfate salt; Geneticin (G418 Sulfate); MFCD00058314; C20H44N4O18S2; G418 Solution; G418 disulfate salt; G-418 disulfate salt; Geneticin sulfate;G418 sulfate; SCHEMBL29360851; UHEPSJJJMTWUCP-NKCAIAFTSA-N; G418 Sulfate; G418; Geneticin; HB3906; AKOS037643634; AG11347; CCG-270379; AC-32603; AS-19117; G-418.Sulfate, Sterile-Filtered Solution; G-2400; M01802; G 418 disulfate salt, plant cell culture tested, BioReagent; G 418 disulfate salt, potency: >=450 mug per mg (dried basis); G 418 disulfate salt, powder, BioReagent, suitable for cell culture; Geneticin Disulfate (G418), Antibiotic for Culture Media Use Only; G 418 disulfate salt, Vetec(TM) reagent grade, potency: >=450 mug per mg (dried basis); (2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-(methylamino)tetrahydropyran-3,5-diol;sulfuric acid; O-2-Amino-2,7-dideoxy-D-glycero-alpha-D-glucoheptopyranosyl-(1-->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-->6)]-2-deoxy-D-streptamine sulfate

Product application:G-418 sulfate,108321-42-2,G418 sulfate,Geneticin sulfate,Geneticin disulfate,Antibiotic G-418,Cell culture grade G418 sulfate,Molecular biology selection agent,Eukaryotic cell selection antibiotic,Neo gene selection,NptII resistance marker,Stable transfection reagent,CHO cell line development,Recombinant protein expression screening,CRISPR Cas9 selection antibiotic,Aminoglycoside antibiotic,Plant tissue culture selection,High potency G418 sulfate 730 ug/mg,G418 solution 50mg/ml,CAS 108321-42-2 supplier,G418 sulfate manufacturer China,Suzhou Health Chemicals biochemical reagents,G418 disulfate wholesale bulk export

 

G-418 Sulfate finds widespread and practical utility across modern molecular biology research, stable mammalian cell line development, industrial biopharmaceutical therapeutic protein bioproduction, stem cell precision gene editing, and transgenic crop biotechnology sectors. In bioprocess engineering and recombinant antibody development, universally designated across biochemical disciplines as Geneticin disulfate, it functions as the standard dominant selection antibiotic; its aminoglycoside molecular framework binds the decoding region of the 80S ribosome in eukaryotes and the 70S ribosome in bacteria, disrupting tRNA proofreading during polypeptide translocation, which leads to widespread translational error, irreversible protein synthesis inhibition, and rapid apoptotic death in sensitive host cells; when target host cells are stably transfected with recombinant expression plasmids bearing aminoglycoside 3'-phosphotransferase resistance genes (such as bacterial neo or nptII cassettes), the expressed enzyme selectively transfers a phosphate group onto the core antibiotic molecule, neutralizing its ribosomal affinity; this enables survival of transfected clones and reliable isolation of high-expression stable cell lines; in commercial biomanufacturing utilizing Chinese hamster ovary (CHO) and human embryonic kidney (HEK293) platforms, it is deployed across screening protocols to isolate and maintain stable clones producing monoclonal antibodies, bispecifics, and recombinant therapeutic enzymes over multi-generation bioreactor campaigns; in advanced genome engineering workflows involving CRISPR-Cas9 knock-in, prime editing, and induced pluripotent stem cell (iPSC) reprogramming, it isolates successfully targeted cell populations, eliminating non-integrated colonies to ensure clean genetic backgrounds; in agricultural plant biotechnology, it is formulated into plant tissue culture media to screen transgenic callus and regenerated shoots in species like rice, maize, and Arabidopsis, suppressing non-transformed tissues; furthermore, in parasitic protozoan genetics, yeast recombination assays, and viral vector titration platforms, biochemical systems utilizing G-418 Sulfate deliver reliable selection kinetics, reproducible dosing curves, and broad multi-industry value.