1-N-Boc-3-Azetidinecarboxylic acid

Product Details

CAS No:142253-55-2

MF:C9H15NO4

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid;Boc-N-Azetidine-3-carboxylic acid;1,3-Azetidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester;1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid, 1-(tert-Butoxycarbonyl)azetane-3-carboxylic acid;1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid;1-Boc-3-Azetidine-3-carboxylic acid;1-(tert-butoxy-oxomethyl)-3-azetidinecarboxylic acid; 142253-55-2; 1-Boc-azetidine-3-carboxylic acid; 1-[(Tert-Butoxy)Carbonyl]Azetidine-3-Carboxylic Acid; DTXSID50373175; 1-((tert-butoxy)carbonyl)azetidine-3-carboxylic acid; RefChem:430111; DTXCID90324207; 675-992-7; 1-N-Boc-3-Azetidinecarboxylic acid; Boc-azetidine-3-carboxylic acid; 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid; n-boc-azetidine-3-carboxylic acid; MFCD01860897; 1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic Acid; 1-tert-butoxycarbonylazetidine-3-carboxylic acid; 1-Boc-Azetidine-3-carboxilic acid; CS-D0672; PB17245; SY014232; 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid; 1-(tert-butoxycarbonyl) azetidine-3-carboxylic acid; 1-(tertiary butoxycarbonyl)azetidine-3-carboxylic acid; azetidine-1,3-dicarboxylic acid mono-tert-butyl ester; 1-n-boc-azetidine-3-carboxylic acid; boc-aze(3)-oh; SCHEMBL43159; 1-(tert-butoxycarbonyl)-3-azetidinecarboxylic acid; boc-3-azetidine carboxylic acid; n-boc-azetidine-3-carboxylicacid; N-Boc-3-Azetidinecarboxylic acid; NCADHSLPNSTDMJ-UHFFFAOYSA-N; 3-CARBOXYAZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER; ALBB-026728; SBB053433; 1-(Boc)-azetidine-3-carboxylic acid; 1-Boc-3-Azetidine-3-carboxylic acid; AKOS004910683; AC-2254; MS-3571; azetidine-1,3-dicarboxylic acid mono-ter; HY-40141; DB-005693; DB-371439; azetidine-3-carboxylic acid, n-boc protected; B3540; 1-t-Butoxycarbonylazetidine-3-carboxylic acid; EN300-74875; VU0494831-1; 1-(t-butoxycarbonyl)-3-azetidinecarboxylic acid; Azetidine-1,3-dicarboxylic acid tert-butyl ester; 1-(t-butoxycarbonyl) azetidine-3-carboxylic acid; F040532; n-(tert-butoxycarbonyl)azetidine-3-carboxylic acid; 1-tert-Butyloxycarbonyl-azetidine-3-carboxylic acid; 1-Boc-azetidine-3-carboxylic acid, >=98.0% (TLC); 1-(T-BUTOXYCARBONYL)AZETIDINE-3-CARBOXYLIC ACID; 1-[(tert-butyl)oxycarbonyl]azetidine-3-carboxylic acid; F2158-1525; AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Product application:1-N-Boc-3-Azetidinecarboxylic acid,142253-55-2,1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid,1-Boc-azetidine-3-carboxylic acid,N-Boc-azetidine-3-carboxylic acid,1-Boc-3-carboxyazetidine,Azetidine derivative,Four-membered nitrogen heterocyclic building block,Boc-protected cyclic amino acid,Pharmaceutical grade 1-Boc-3-azetidinecarboxylic acid,KRAS G12C inhibitor intermediate,PROTAC linker synthon,Targeted oncology API intermediate,Kinase inhibitor building block,Unnatural amino acid mimetic,Drug-like fragment building block,Fine organic chemical intermediate,High purity 1-Boc-3-Azetidinecarboxylic acid 99%,1-N-Boc-3-Azetidinecarboxylic acid manufacturer China,CAS 142253-55-2 supplier,Suzhou Health Chemicals specialty chemicals,1-Boc-3-azetidinecarboxylic acid wholesale bulk export

 

1-N-Boc-3-Azetidinecarboxylic acid serves as an indispensable, ultra-pure strained heterocyclic building block, premier active pharmaceutical ingredient (API) intermediate, and versatile conformational constraint synthon extensively utilized across targeted oncology discovery, PROTAC protein degrader development, kinase inhibitor synthesis, and peptidomimetic engineering sectors. In synthetic medicinal chemistry and pharmaceutical process research, universally recognized as 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid, its molecular architecture incorporates a strained four-membered saturated azetidine ring functionalized with an orthogonal tert-butoxycarbonyl (Boc) protecting group on the ring nitrogen and a reactive carboxylic acid handle at the C3 position; this dual functionality enables direct, chemoselective amide coupling or esterification with core pharmacophores under mild conditions, followed by clean, bio-orthogonal acidolytic deprotection of the Boc moiety to unmask the secondary amine for downstream diversification; the rigid, puckered geometry of the azetidine core restricts excessive torsional degrees of freedom within drug candidate side-chains, significantly optimizing spatial binding complementarity with protein active sites, elevating aqueous thermodynamic solubility, mitigating metabolic clearance pathways, and lowering off-target liabilities in blockbuster KRAS G12C inhibitors, Bruton's tyrosine kinase (BTK) modulators, and JAK inhibitors. In targeted protein degradation (TPD) platform engineering, it acts as a rigid, low-molecular-weight structural spacer within PROTAC chemical linkers, precisely directing the spatial alignment and dihedral orientation between E3 ubiquitin ligase-recruiting moieties and target oncoproteins to drive efficient ternary complex formation and proteasomal degradation. In peptidomimetic science, incorporating this cyclic unnatural amino acid surrogate into linear or macrocyclic peptide therapeutics introduces stable conformational turns that dramatically enhance stability against serum proteolytic cleavage. Furthermore, in fluorescent bioimaging probe design, chiral ligand coordination frameworks, and high-value fine chemical syntheses, molecular architectures engineered from 1-N-Boc-3-Azetidinecarboxylic acid deliver exceptional chemical fidelity, reproducible reaction kinetics, and broad multi-industry performance.