L-Homocysteine thiolactone hydrochloride

Product Details

CAS No:31828-68-9

MF:C4H7NOS.HCl

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:L-Homocysteine thiolactone hydrochloride,L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride;CAindexname:2(3H)-Thiophenone,3-aminodihydro-,hydr;(S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride;L-HOMOCYSTEINE THIOLACTONE HCL*CRYST;-3-Aminodihydrothiophen-2(3H);H-HOCYS-THIOLACTONE HCL;2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, (3S)-;2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE, L-; 31828-68-9; L-Homocysteine thiolactone hydrochloride; (S)-3-Aminodihydrothiophen-2(3H)-one hydrochloride; L-homocysteine thiolactone HCl; (S)-3-Aminodihydrothiophen-2(3H)-one HCl; (3S)-3-aminothiolan-2-one;hydrochloride; Homocysteine thiolactone hydrochloride, L-; 2HTL9Q12FE; L-Homocysteine thiolactone (hydrochloride); DTXSID60953745; CS-6394; MFCD00065494; HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE, (+)-; UNII-2HTL9Q12FE; (3S)-3-Aminodihydro-2(3H)-thiophenone Hydrochloride; (S)-3-Aminodihydro-2(3H)-thiophenone Hydrochloride; L-3-Aminodihydro-2(3H)-thiophenone Hydrochloride;; EINECS 250-824-1; L-2-Amino-4-me; A919235; SCHEMBL185765; D-Homocysteine thiolactone-HCl; orb1706153; orb2901552; 2338-04-7(Free Base); MSK170042A; AKOS015950984; EBC-280054; HY-101404A; AS-49937; FL138522; PD103002; NS00084087; rel-(3R)-3-aminothiolan-2-one hydrochloride; O10218; T19393; 3-Aminothiolan-2-one--hydrogen chloride (1/1); F222430; (3S)-3-aminotetrahydrothiophen-2-one;hydrochloride; (3S)-3-Aminothiolan-2-one--hydrogen chloride (1/1); Q27254763; (S);-3-Aminodihydrothiophen-2(3H);-one hydrochloride; L-Homocysteine thiolactone hydrochloride, >=98% (TLC); Z5069354967; HOMOCYSTEINE L-FORM THIOLACTONE HYDROCHLORIDE [MI]; L-Homocysteine thiolactone hydrochloride, >=99.0% (TLC); 2(3H)-THIOPHENONE, 3-AMINODIHYDRO-, HYDROCHLORIDE (1:1), (3S)-

Product application:L-Homocysteine thiolactone hydrochloride,31828-68-9,(S)-(-)-alpha-Amino-gamma-butyrothiolactone hydrochloride,L-Homocysteine thiolactone HCl,H-Hcy-thiolactone.HCl,Chiral amino acid derivative,Sulfur heterocyclic building block,Homocysteine assay calibrator,IVD diagnostic reference material,Cardiovascular biomarker standard,Chiral pharmaceutical intermediate,Antithrombotic drug synthon,Hepatoprotective agent intermediate,Protein thiolation reagent,Polymer ring-opening functionalization,Bioconjugation crosslinker,Biotinylation activation reagent,Thiol-bearing molecular fragment,High optical purity intermediate,High purity L-Homocysteine thiolactone hydrochloride 99.5%,CAS 31828-68-9 supplier,L-Homocysteine thiolactone hydrochloride manufacturer China,Suzhou Health Chemicals specialty chemicals,L-Homocysteine thiolactone HCl wholesale bulk export

 

L-Homocysteine thiolactone hydrochloride serves as an indispensable, ultra-pure chiral sulfur-heterocyclic building block, clinical diagnostic benchmark calibrator, and versatile bioconjugation thiolation reagent extensively utilized across clinical in vitro diagnostic (IVD) assays, cardiovascular biomarker testing, pharmaceutical API total synthesis, targeted protein thiolation engineering, and smart biomaterial hydrogel sectors. In clinical diagnostic laboratory science and cardiovascular disease pathology, elevated systemic concentrations of total homocysteine (Hcy) represent a critical and independent biomarker for premature atherosclerosis, ischemic stroke, deep vein thrombosis, and hyperhomocysteinemia; this compound functions as the gold-standard primary reference material and internal calibrator in automated enzymatic cycling assays, chemiluminescence immunoassay platforms, and liquid chromatography-tandem mass spectrometry (LC-MS/MS) panels, where its rigorous S-enantiomeric purity and instant aqueous solubility deliver linear calibration fidelity, analytical sensitivity, and long-term calibration shelf-life. In synthetic medicinal chemistry and active pharmaceutical ingredient (API) manufacturing, its molecular architecture combines an optically active alpha-amino center with a reactive five-membered thiolactone ring, functioning as an essential chiral synthon for constructing antithrombotic candidates, cardioprotective therapeutics, hepatoprotective agents, and neuroactive pharmaceuticals. In bioconjugate chemistry and protein engineering, it is widely deployed as a gentle and highly efficient protein thiolation crosslinker; under physiological neutral to mildly alkaline aqueous buffers, the electrophilic carbonyl of its thiolactone ring undergoes rapid nucleophilic acylation specifically targeted by solvent-accessible primary amines on lysine residues of monoclonal antibodies, albumin, or peptide hormones, simultaneously forging a stable amide linkage while releasing an unmasked, nucleophilic free sulfhydryl (-SH) thiol group; this newly generated thiol handle provides an ideal anchor for downstream maleimide-based Michael additions, fluorescent dye tagging, biotinylation, or controlled antibody-drug conjugate (ADC) payload attachment. In regenerative biomaterials and polymer engineering, it is deployed to graft pendant thiol handles onto polysaccharide and synthetic backbones such as hyaluronic acid, chitosan, and multi-arm polyethylene glycol, generating shear-thinning and redox-responsive hydrogels tailored for surgical sealants, mucoadhesive delivery matrices, and tissue engineering scaffolds. Furthermore, in self-assembled monolayers (SAMs) on noble metal surfaces, functional nanoparticle capping architectures, and specialized organosulfur sensory coatings, chemical systems engineered from L-Homocysteine thiolactone hydrochloride deliver exceptional enantiomeric integrity, reproducible ring-opening kinetics, and broad multi-industry value.