Glycinamide

Product Details

CAS No:598-41-4

MF:C2H6N2O

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Product application:Glycinamide, 598-41-4, Glycinamide HCl, Aminoacetamide, Glycinamide free base, Glycinamide manufacturers, Glycinamide supplier, High purity Glycinamide, Glycinamide for synthesis, Pharmaceutical grade Glycinamide, Intermediate for Milrinone, Intermediate for Azacitidine, Polypeptide synthesis reagent, Glycinamide chemical properties, Buy Glycinamide online, Glycinamide global shipping.

Synonyms:Glycinamide; 2-Aminoacetamide; 2-Aminoacetamide;Acetamide, 2-amino-;Glycinamide;AMINOACETAMIDE;2-amino-acetamid;2-Amino-1-iminoethanol;Aminoacetimidic acid;2-azanylethanamide; Glycinamide,"Glycinamide; 2-Aminoacetamide; 598-41-4; Glycine amide; Acetamide, 2-amino-; AMINOMETHYLAMIDE; 4JDT453NWO; CHEBI:42843; DTXSID1060508; DTXCID4042701; 209-932-4; GLYCINAMID; 2-Amino-Acetamide; MFCD01859715; aminoacetamide; Acetamide, 2-amino-, monohydrochloride; UNII-4JDT453NWO; glycineamide; glycine imine; glycine-amide; alpha-aminoacetamide; EINECS 209-932-4; GlyNH2; 2-Aminoacetamide #; Gly-NH2; Glycineamide, G-NH2; 2-Aminoacetimidic acid; AI3-60342; Glycine amide hydrobromide; H2NCH2CONH2; SCHEMBL8299; 4463-18-7; CHEMBL86954; SCHEMBL242507; methane, C-amino-C-carbamoyl-; SCHEMBL1289792; SCHEMBL1781782; SCHEMBL3927405; SCHEMBL5518651; SCHEMBL9730971; SCHEMBL18335287; SCHEMBL22345974; SCHEMBL29511532; NSC 9225; EINECS 216-789-1; BP-11918B; AKOS008953605; DB03636; SY104505; CS-0149938; NS00034250; EN300-34291; Q27094555",74.080,C2H6N2O,

 

Applications:
Glycinamide is a key organic synthetic intermediate, playing a vital role in the fine chemical and biopharmaceutical industries. Its chemical structure contains a free amino group and an amide group, giving it extremely high reactivity, enabling it to participate in various condensation, cyclization, and substitution reactions. As a basic amino acid derivative, glycinamide provides a stable nitrogen scaffold for the construction of complex molecules while maintaining biocompatibility.

 

1. In the pharmaceutical synthesis industry, glycinamide is primarily used as a core intermediate for the cardiovascular drug milrinone. By participating in cyanoacetylation and subsequent cyclization reactions, glycinamide can efficiently construct pyridone ring systems, thereby ensuring the purity and yield of milrinone, making it indispensable in the production of clinical cardiotonic drugs.

2. In the field of antitumor drugs, glycinamide is widely used in the synthesis of azacitidine and norazacitidine. Utilizing the stability of its amide group and the nucleophilicity of its amino group, it serves as part of the molecular backbone in the construction of nucleoside analogs, playing a crucial supporting role in the synthesis of drugs for the treatment of myelodysplastic syndromes.

3. Glycinamide plays a crucial role in biochemical research and peptide synthesis. It is frequently used as a C-terminal amidation agent to prepare bioactive amidated peptides. This structural modification enhances peptide stability in vivo, reduces the rate of enzymatic degradation, and improves the bioavailability of targeted drugs.

4. In the agrochemical field, glycinamide is used to synthesize novel, low-toxicity pesticide intermediates. Its active sites can condense with heterocyclic compounds to develop highly selective herbicides or fungicides, helping to reduce pesticide residues and improve agricultural safety.

5. In the fine chemicals and auxiliaries industry, glycinamide is used to produce crosslinking agents or functional monomers for polymers. Due to the simultaneous presence of amino and amide bonds within its molecule, it can improve the adsorption properties or hydrophilicity of high-performance materials, increasing the added value of coatings or textile auxiliaries.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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