Bergamottin

Product Details

CAS No:7380-40-7

MF:C21H22O4

Appearance:white or light-yellow crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:KGS

Synonyms:BERGAMOTINE;5-GERANYLOXYPSORALEN;4-GERANYLOXYPSORALEN;AKOS 214-13;GF-I-2;BERGAMOTIN WITH HPLC;Bergamotine, Bergaptin;4-[[(E)-3,7-Dimethyl-2,6-octadienyl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one; Bergamottin; 7380-40-7; Bergamotine; Bergaptin; 5-Geranoxypsoralen; Bergamotin; 4-[(2E)-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one; JMU611YFRB; DTXSID50897528; 4-{[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one; 7H-furo(3,2-g)(1)benzopyran-7-one, 4-(((2E)-3,7-dimethyl-2,6-octadien-1-yl)oxy)-; 4-((2E)-3,7-dimethylocta-2,6-dienoxy)furo(3,2-g)chromen-7-one; 4-(((2E)-3,7-dimethylocta-2,6-dien-1-yl)oxy)-7H-furo(3,2-g)chromen-7-one; 7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-; RefChem:29717; 5-(((2Z)-3,7-dimethylocta-2,6-dien-1-yl)oxy)-2H-furo(3,2-g)chromen-2-one; DTXCID601326883; 866-344-6; 5-Geranyloxypsoralen; Bergomottin; MFCD00017409; CHEMBL1078442; 4-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g][1]benzopyran-7-one; (E)-4-((3,7-Dimethylocta-2,6-dien-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one; UNII-JMU611YFRB; CCRIS 8085; 4-Geranyloxypsoralen; Bergamottin (Standard); BERGAMOTTIN [MI]; SCHEMBL569529; orb1301329; orb3139847; Bergamottin, analytical standard; SCHEMBL29556462; CHEBI:70476; HY-N2194R; HY-N2194; TNP00285; 4-[(2Z)-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one; BDBM50310823; LMPK12160611; MSK175219; NSC710599; AKOS000277132; EBC-476054; FB65517; NSC-710599; T5S0669; 5-Geranoxypsoralen;Bergamotine;Bergaptin; NCGC00017345-01; NCGC00161832-01; AC-34220; B3943; CS-0019502; C22152; F795464; Q568006; 4-([(2E)-3,7-dimethyl-2,6-octadienyl]oxy)-7h-furo[3,2-g]chromen-7-one; 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-

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Bergamottin is a prominent naturally occurring furanocoumarin abundant in citrus bergamia and grapefruit peel, exhibiting highly specific pharmacological, biochemical, and synthetic utility across advanced life science, pharmaceutical, and consumer product industries. In the realm of biomedical research and drug metabolism pharmacokinetics (DMPK), it serves as a globally recognized benchmark mechanism-based irreversible inactivator of the cytochrome P450 3A4 (CYP3A4) enzyme system, playing an indispensable role in elucidating the clinical grapefruit-drug interaction phenomenon, assessing metabolic stability, and profiling drug-drug interactions in preclinical lead optimization pipelines. By selectively attenuating intestinal first-pass metabolic degradation, it is extensively investigated as a strategic bioenhancer to amplify the oral systemic bioavailability of poorly absorbed active pharmaceutical ingredients, while simultaneously presenting notable pharmacological activities in downregulating inflammatory cytokine cascades, suppressing osteoclast-mediated bone resorption, and inducing targeted cell apoptosis in resistant oncological models. In the food, beverage, and sensory flavor sectors, bergamottin is applied as an authentic aroma standard and signature flavor modifier for citrus-type formulations, aiding in the balance of characteristic bitterness, citrus astringency, and authentic fresh notes. In cosmetics, personal care, and dermatological safety assessments, it functions as a primary reference substance for identifying and quantifying phototoxicity and photoallergic mechanisms associated with natural essential oils and perfumery bases, while being investigated for its direct free-radical quenching and skin-protective properties. In specialty organic synthesis and functional biomaterials, its reactive geranyloxy side chain and rigid planar coumarin core facilitate its utilization as a versatile molecular scaffold in preparing targeted fluorescent bioprobes, supramolecular host-guest recognition assemblies, and responsive photoreactive functional materials.