HATU

Product Details

CAS No:148893-10-1

MF:C10H15F6N6OP

Appearance:white or off-white crystalline powder

Specification:99.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:MT

Synonyms:HATU >=98.0% (CHN);O-(7-AZABENZOTRIAZOLE-1-YL)-N, N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPATE;HATU impregnated tablets, N,N,Nμ,Nμ-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate impregnated tablets, ChemDose(R) O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate tablets, O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate impregnated tablets;O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate, ChemDose(R) tablets;O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%;O-(7-Azabenzotriazol-1-yl)-N,N,N',N'- tetramethyluronium hexaflu; B93RIH1T7E; N-HATU; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-Oxide Hexafluorophosphate; DTXSID30933498; 1H-1,2,3-Triazolo(4,5-b)pyridinium, 1-(bis(dimethylamino)methylene)-, hexafluorophosphate(1-), 3-oxide; O-(7-AZOBENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; 1-(BIS(DIMETHYLAMINO)METHYLENE)-1H-1,2,3-TRIAZOLO(4,5-B)PYRIDINIUM 3-OXIDE HEXAFLUOROPHOSPHATE (1-) (1:1); 1-(Bis(dimethylamino)methylene)-1H-1,2,3-triazolo(4,5-b)pyridinium 3-oxide hexafluorophosphate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo(4,5-b)pyridinium 3-oxide hexafluorophosphate; O-HATU cpd; RefChem:6076; O-(7-azabenzotriazol-1-yl)-N,N,N;,N'-tetramethyluronium hexafluorophosphate; 604-662-7; n-((1h-1,2,3-triazolo-(4,5-b)pyridin-1-yloxy)(dimethylamino)methylene)n-methylmethanaminium hexafluorophosphate; 148893-10-1; HATU; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-(bis(dimethylamino)methylene)-1H-[1,2,3]triazolo[4,5-b]pyridine-1-ium 3-oxide hexafluorophosphate(V); HATU [MI]; UNII-B93RIH1T7E; SCHEMBL1176759; SCHEMBL19617662; SCHEMBL19970593; SCHEMBL29408871; SCHEMBL29854425; SCHEMBL41936761; SCHEMBL41941338; HATU, 97%; FKBFHOSFPRWJNV-UHFFFAOYSA-N; AKOS030214190; HATU, >=98.0% (CHN); [dimethylamino-(3-oxidotriazolo[4,5-b]pyridin-3-ium-1-yl)methylidene]-dimethylazanium;hexafluorophosphate; O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-; P17135; o-(7-azabenzotriazol-1-yl)-n,n,n,n-tetramethyluroniumhexafluorophosphate; (dimethylamino)-N,N-dimethyl(3-oxido-1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)methaniminium hexafluorophosphate; 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V); 1-[bis(dimethylamino)-methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate; 1-[bis(dimethylamino)methylene]-1h-1,2,3-triazolo [4,5-b]pyridinium-3-oxide hexafluoro-phosphate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo-[4,5-b]pyridinium 3-oxid hexafluorophosphate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridin-1-ium 3-oxide hexafluorophosphate; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, ChemDose(TM) tablets, Loading: 0.02mmol per tablet; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxid hexafluorophosphate; 1-[bis(dimethylamino)methylene]-1h-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluoro-phosphate; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxide hexafluorophosphate; 1-[Bis(dimethylamino)methylidene]-3-oxo-1H-3lambda~5~-[1,2,3]triazolo[4,5-b]pyridin-1-ium hexafluoridophosphate(1-); 1-[bis(dimethylamino)methyliumyl]-1H-1,2,3-triazolo[4,5-B]pyridine-3-oxide hexafluorophosphate; bis(dimethylamino)(3-oxido-1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)methylium hexafluorophosphate

Product application:2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate,148893-10-1,HATU,O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate,1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate,Peptide coupling reagent,Solid phase peptide synthesis reagent,SPPS coupling agent,Liquid phase peptide synthesis,Low racemization condensing agent,Sterically hindered amidation reagent,Cyclic peptide macrocyclization agent,ADC linker coupling reagent,PDC conjugation synthon,Carboxylic acid activating agent,High purity HATU 99.5%,Low moisture HATU,CAS 148893-10-1 supplier,HATU manufacturer China,Suzhou Health Chemicals peptide reagents,HATU wholesale bulk export

 

2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate is widely utilized across commercial therapeutic peptide drug manufacturing, solid-phase and liquid-phase fragment condensation processes, cyclic peptide macrocyclization chemistry, antibody-drug conjugate (ADC) linker bioconjugations, and sterically hindered chiral pharmaceutical amidation sectors. In peptide science and process medicinal chemistry, universally recognized in biopharma as HATU, it represents a premier, benchmark uronium/guanidinium-type coupling reagent engineered for rapid kinetics and high chiral preservation; the strategic presence of the pyridine nitrogen atom within its 7-azabenzotriazole scaffold delivers a potent neighboring-group catalytic effect that accelerates carboxylic acid activation into a reactive ester intermediate; this electronic assistance drives clean amidation across highly congested, sterically hindered substrates such as N-methylated and alpha,alpha-dialkyl amino acids, achieving quantitative coupling yields within minutes while suppressing enantiomeric racemization below detection thresholds; in targeted oncology and bioconjugation technologies, it serves as an indispensable activating agent for coupling potent antineoplastic payloads onto specialized peptidic linkers in ADCs and peptide-drug conjugates (PDCs); furthermore, in nucleotide analogue engineering and complex natural product total synthesis, 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate delivers reliable amidation efficiency and robust functional performance across demanding industrial environments.