(-)-Corey lactone diol

Product Details

CAS No:32233-40-2

MF:C8H12O4

Appearance:white or off-white crystalline powder

Specification:98.5%

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:(-)-Corey lactone diol; (-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; (-) COREY LACTONE DIOL;(-)-COREY LACTONE DIOL,98%;(3AR,4S,5R,6AS)-(-)-HEXAHYDRO-5-HYDROXY-4--2H-CYCLOPENTA(B)FURAN-2-ONE,;(1R)-2β-(Hydroxymethyl)-3α,5α-dihydroxycyclopentane-1α-acetic acid 1,5-lactone;(1S,5R,6S,7R)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one;(3aβ,4S,6aβ)-4β-(Hydroxymethyl)-5α-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one;(-)-6beta-Hydroxymethyl-7alpha-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one,98%;(+)-6β-Hydroxymethyl-7α-hydroxy-cis-2-oxabicyclo[3.3.0]octan-3-one; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one","(3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one; (3aR,4S,5R,6aS)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one; 608-721-8; 32233-40-2; (-)-Corey lactone diol; (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one; Corey lactone Diol; (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one; MFCD00075234; 54423-47-1; (1S,6S,5R,7R)-7-hydroxy-6-(hydroxymethyl)-2-oxabicyclo[3.3.0]octan-3-one; (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-hexahydro-2H-cyclopenta[b]furan-2-one; (3aR,4S,5R,6aS)Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; [3aR-(3aalpha,4alpha,5beta,6aalpha)]Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one;; rel-Coreylactonediol; (-) Corey lactone; (-)-Coreylactonediol; rel-Corey lactone diol; Bimatoprost Impurity 9; Corey lactone diol, (-)-; SCHEMBL439263; orb1299234; R78KQ4P7T9; DTXSID10369135; CHEBI:167719; s5335; AKOS015900009; AKOS016015263; AC-6090; CCG-266367; CS-W008393; DS-5112; FC29747; HY-W008393; ST075172; SY028945; H1418; NS00015091; F20511; (3aR,4S, 5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-hydroxymethyl-2H-cyclopenta[b]furan-2-one; 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)-; (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, 98%; (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]uran-2-one; 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-(hydroxymethyl)-, [3aR-(3aalpha,4alpha,5beta,6aalpha)]-",172.180,C8H12O4,;

Applications:
(-)-Corey lactone diol (CAS No. 32233-40-2) is one of the most critical chiral intermediates in the synthesis of prostaglandin drugs. Featuring a stable lactone structure and two modifiable hydroxyl functional groups, it serves as the core precursor for constructing the prostaglandin backbone. Due to its high chiral purity and well-defined chemical reactivity, this compound is extensively utilized in medicinal chemistry to synthesize various naturally occurring and synthetic prostaglandin analogues with significant biological activities.

1.    Prostaglandin Drug Synthesis: Acts as a key starting material or core intermediate for synthesizing drugs like Latanoprost, Travoprost, and Beraprost used in ophthalmology and cardiovascular therapy.
2.    Chiral Drug Development: Used as a chiral pool in medicinal chemistry to construct complex chiral molecules through hydroxyl protection, oxidation, or functional group transformation.
3.    Anti-glaucoma Research: Specifically utilized in the synthesis of specific prostaglandin derivatives designed to lower intraocular pressure.
4.    Chemical Biology: Employed in the synthesis of labeled bioactive molecules to study signaling pathways of prostaglandin receptors in vivo.
5.    Organic Synthesis Intermediate: Utilized in general organic synthesis for developing novel asymmetric synthetic routes and molecular construction strategies.