L-Valine N-carboxyanhydride

Product Details

CAS No:24601-74-9

MF:C6H9NO3

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:MT

Synonyms:2,5-Oxazolidinedione, 4-(1-methylethyl)-, (4S)-; RefChem:445043; 607-408-3; 24601-74-9; L-Valine N-Carboxyanhydride; MFCD03411320; (4S)-4-propan-2-yl-1,3-oxazolidine-2,5-dione; DTXSID00432488; (4S)-4-(Propan-2-yl)-1,3-oxazolidine-2,5-dione; (4S)-4-Isopropyloxazolidine-2,5-dione; AKOS016843858; (S)-4-Isopropyl-oxazolidine-2,5-dione; CS-16607; CS-0101223; N-Carboxy-L-valine Anhydride; Valine N-Carboxyanhydride;; DL-valine NCA; AMY22687; Val-NCA; N-carboxy-DL-valine anhydride; 2,5-Oxazolidinedione, 4-(1-methylethyl)-, (S)-; SCHEMBL2071787; ZAA60174; AC5719; (S)-4-isopropyl-2,5-oxazolidinedione; SY062319; NS00045753; F319395

Product application:L-Valine N-carboxyanhydride,24601-74-9,L-Val-NCA,Val-NCA,Valine N-carboxyanhydride,N-Carboxy-L-valine anhydride,(4S)-4-Isopropyloxazolidine-2,5-dione,(S)-4-Isopropyl-1,3-oxazolidine-2,5-dione,Ring-opening polymerization monomer,ROP monomer,Poly-L-valine precursor,Polypeptide biomaterial monomer,Nanomedicine carrier block,Peptide hydrogel building block,Protecting-group-free peptide synthesis,Leuchs anhydride,Low chloride Val-NCA,High purity L-Val-NCA 99.5%,Ultra-dry amino acid NCA,CAS 24601-74-9 supplier,L-Valine N-carboxyanhydride manufacturer China,Suzhou Health Chemicals bio-monomers,Valine NCA wholesale bulk export

 

L-Valine N-carboxyanhydride finds widespread and practical utility across commercial bio-functional polypeptide macromolecular synthesis, smart targeted nanomedicine delivery systems, protecting-group-free high-efficiency peptide segment couplings, biomimetic tissue engineering hydrogel scaffolds, and advanced chiral polymer surface functionalization sectors. In biomaterials science and synthetic protein mimetic engineering, universally designated as L-Val-NCA or Val-NCA, it functions as an essential Leuchs anhydride monomer for precision controlled ring-opening polymerization (ROP); its molecular architecture features the carboxyl and amino handles of L-valine cyclized into a reactive five-membered oxazolidine-2,5-dione ring, providing self-activation of the acyl center while masking the primary amine; upon initiation with primary nucleophilic amines or organometallic catalysts in anhydrous aprotic media, it undergoes controlled chain-growth polymerization accompanied by the spontaneous evolution of gaseous carbon dioxide as the sole, non-toxic byproduct, eliminating the requirement for classical multi-step coupling reagents and side-chain masking protocols; this allows scalable production of high-molecular-weight poly-L-valine homopolymers and block copolypeptides with defined sequence lengths and low polydispersity indices; driven by the strong steric hydrophobicity and stable beta-sheet secondary structure preferences dictated by its homochiral isopropyl side chain, this monomer is copolymerized with hydrophilic blocks like poly(ethylene glycol) (PEG) or poly(glutamic acid) to engineer stimuli-responsive amphiphilic nano-micelles; these core-shell nanostructures achieve high loading efficiencies for hydrophobic small-molecule antineoplastic agents and delicate biotherapeutic cargos, enhancing systemic circulatory half-lives and enabling targeted payload release within tumor microenvironments; in regenerative medicine and 3D cell scaffolding, dynamic hydrogels fabricated from this NCA monomer replicate native extracellular matrix properties, offering tunable mechanical moduli and biocompatible degradation profiles into endogenous nutrient metabolites; in modern peptide process chemistry, it operates as an atom-economical coupling synthon for installing terminal valyl motifs onto growing polypeptide chains in continuous fluidics without toxic condensation additives; furthermore, in chiral separation membranes, artificial transmembrane ion-channel architectures, and protein-resistant antifouling thin films, macromolecular matrices engineered from L-Valine N-carboxyanhydride deliver stereochemical fidelity, reproducible polymerization kinetics, and broad multi-industry value.