1-Hydroxybenzotriazole; HOBT

Product Details

CAS No:2592-95-2

MF:C6H5N3O

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:MT

Synonyms:1-Hydroxybenzotriazole 〔HBT〕;1-HYDROXYBENZOTRIAZOL;1-HYDROXYBENZOTRIAZOLE;1-HYDROXY-1-H-BENZOTRIAZOLE;1-HYDROXY-1,2,3-BENZOTRIAZOLE;1-HOB;1H-Benzotriazol-1-ol;Benzazimidol; 1-Hydroxybenzotriazole; 2592-95-2; HOBt; Benzazimidol; 1H-Benzotriazole, 1-hydroxy-; DTXSID3044627; A2T929DMG4; DTXCID1024627; RefChem:76020; 219-989-7; 1H-Benzo[d][1,2,3]triazol-1-ol; 1H-1,2,3-Benzotriazol-1-ol; 1H-Benzotriazol-1-ol; N-Hydroxybenzotriazole; 1-Hydroxy-1H-benzotriazole; 1-Benzotriazolol; Sitagliptin Impurity 47; benzotriazol-1-ol; 1-HYDROXY-BENZOTRIAZOLE; 1-hydroxybenztriazole; 1-Hydroxybenzotrizole; N-Hydroxybenzotriazole hydrate; 1-Hydroxy-1H-benzotriazole hydrate; 1-Hydroxy-1,2,3-benzotriazole; 1-HYDROXY-1-H-BENZOTRIAZOLE; 1H-1,2,3-benzotriazole, 1-hydroxy-; Benzazimidol hydrate; N-Hydroxybenzotriazol; 1-hydroxybenzotriazol; CCRIS 2605; 1-hydroxy benzotriazole; 1H-BENZOTRIAZOLE, HYDROXY-; EINECS 219-989-7; 1-Hydroxy-1H-benzotriazol; benzotriazolol; BRN 0004515; 1-hydroxyl-1H-benzotriazole; UNII-A2T929DMG4; 1,2,3-Benzotriazol-1-ol; benztriazol-1-ol; 1-hydroxybenztriazol; N-hydoxybenzotriazole; N-hydroxybenztriazole; N-Hydroxybezotriazole; 1-hydoxybenzotriazole; 1-hydroxibenzotriazol; 1-hydroxybenzothazole; 1-hydroxybezotriazole; 1-hyroxybenzotriazole; benzotriazole n-oxide; HOBO; l-hydroxybenzotriazole; 1hydroxy-benzotriazole; 3-hydroxybenzotriazole; N-hydroxy-benzotriazol; 1-hydroxy benzotriazol; 1-hydroxy benztriazole; 1-hydroxy-benztriazole; 1-hydroxy-bezotriazole; 1-hydroxybenztria zole; 1-hydroxylbenzotriazole; N-hydroxy benzotriazole; N-hydroxy-benzotriazole; 1 -hydroxybenzotriazole; 1- hydroxybenzotriazole; 1-hydroxybenzo-triazole; 1-hydroxybenzotri-azole; 1H-benzotriazole-1-ol; N-hydroxyl-benzotriazole; 1-N-Hydroxybenzotriazole; 1-hydroxy-benzo-triazole; SCHEMBL184; 1-hydroxy-1H-benztriazole; hydroxybenzotriazole (HOBt); SCHEMBL34349; SCHEMBL43714; MLS001006716; 1-hydroxy-(1H)-benzotriazole; SCHEMBL1306975; SCHEMBL2845655; SCHEMBL3295216; SCHEMBL3672275; CHEMBL1389920; CHEBI:176967; 1-H-1,2,3-benzotriazol-1-ol; 1-hydroxy-benzo-1,2,3-triazole; HMS1724G04; HMS2742F11; ALBB-013485; CS-B0704; Tox21_302480; 1-hydroxy-1H-1,2,3-benzotriazole; NSC778225; SBB056385; 1H-benzo[d][1,2,3]triazole-1-ol; AKOS000120715; AC-2558; NSC-778225; 1-HYDROXY-1H-BENZOTRIAZOLE [MI]; NCGC00246157-01; NCGC00256701-01; BP-12840; SMR000349651; CAS-2592-95-2; H0468; NS00007863; EN300-17272; AB-131/40192094; Q161641; 1-HYDROXYBENZOTRIAZOLE (WET WITH 14% WATER); 1-Hydroxybenzotriazole(Discontinued,See C4X-113571); 1H-1,2,3-Benzotriazol-1-ol (wet with 14% water); Z56900935; 1-Hydroxybenzotriazole (hobt) (wetted with ~20% water); F0001-2469; 1-Hydroxybenzotriazole;N-Hydroxybenzotriazole; 1-Hydroxy-1H-benzotriazole; 1-Hydroxybenzotriazole anhydrous

Product application:1-Hydroxybenzotriazole,HOBt,HOBt hydrate,CAS 2592-95-2,1-Hydroxy-1H-benzotriazole,peptide coupling reagent,peptide synthesis additive,racemization suppressor,amide bond formation,solid phase peptide synthesis SPPS,liquid phase peptide synthesis LPPS,coupling additive for DCC,EDC HOBt coupling,DIC peptide synthesis reagent,pharmaceutical intermediates supplier,fine chemicals manufacturer,high purity HOBt,wet peptide reagent,China chemical exporter,peptide API synthesis,amino acid coupling catalyst,anti racemization additive,China HOBt bulk price,Suzhou chemical supplier,organic synthesis building block,chemical raw materials wholesale,custom peptide reagents

 

1-Hydroxybenzotriazole is an indispensable nucleophilic additive and coupling agent extensively utilized in peptide chemistry, pharmaceutical manufacturing, and complex organic synthesis. It plays a pivotal role in solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS) by suppressing racemization during amino acid coupling. When combined with classic carbodiimide activating agents such as DCC, EDC, or DIC, it rapidly intercepts the transient O-acylisourea intermediate to generate a highly reactive yet stereochemically stable active ester. This pathway dramatically accelerates amide bond formation, maximizes coupling yields, and effectively eliminates unwanted epimerization and oxazolone-mediated side reactions. Beyond standardized peptide and peptide-based active pharmaceutical ingredient (API) production, it is widely utilized in macrocyclization reactions, esterification, functional modification of biopolymers, and selective acylation processes across industrial medicinal chemistry.