2-Methylalanine

Product Details

CAS No:62-57-7

MF:C4H9NO2

Appearance:white or off-white crystalline powder

Specification:98.5%

UN number:-

Package:1/5/10/25kgs/drum

Supply Capacity:Tons

Synonyms:N-ME-ALANINE;N-ME-ALA-OH;RARECHEM EM WB 0051;DL-2-AMINO-ISO-BUTYRIC ACID;H-2-AMINOISOBUTYRIC ACID;H-ALA(ME)-OH;H-AIB-OH;H-ALPHA-METHYLALANINE

Product application:2-Aminoisobutyric acid,62-57-7,alpha-Aminoisobutyric acid,Aib,2-Methylalanine,alpha-Methylalanine,Non-proteinogenic amino acid,Unnatural amino acid,Conformationally constrained amino acid,Alpha-helix inducer,Peptide synthesis building block,GLP-1 intermediate,Semaglutide intermediate,Tirzepatide building block,SPPS peptide reagent,Enzymatic degradation resistant peptide modifier,Peptidomimetic intermediate,Pharmaceutical intermediate CAS 62-57-7,High purity Aib powder,Plant growth regulator intermediate,Agrochemical raw material,Research biochemical,2-Aminoisobutyric acid manufacturer China,CAS 62-57-7 supplier,Suzhou Health Chemicals peptide building blocks,Aib wholesale bulk export

 

2-Aminoisobutyric acid serves as an indispensable non-proteinogenic, conformationally constrained amino acid building block across the peptide therapeutics, biopharmaceutical engineering, chemical biology, and advanced agrochemical industries. In the commercial manufacturing of modern peptide pharmaceuticals, its unique gem-dimethyl alpha-carbon substitution exerts strong steric hindrance that robustly induces and stabilizes alpha-helical and 3-10 helical secondary structures within peptide backbones; more importantly, the incorporation of this building block confers superior metabolic stability against proteolytic cleavage by enzymes such as dipeptidyl peptidase-4 (DPP-4), dramatically prolonging physiological circulating half-life and target receptor binding affinity, which makes it a crucial starting intermediate for blockbuster GLP-1 receptor agonists and dual/triple incretin mimetics including Semaglutide and Tirzepatide, as well as targeted antimicrobial peptides and oncology therapeutics. In peptidomimetic design and biochemical research, it functions as a vital structural tool for rigidifying flexible loops, probing ion-channel gating mechanisms, and constructing biomimetic transmembrane channel-forming peptide sequences such as alamethicins. Furthermore, in agrochemical sciences and plant physiology, 2-Aminoisobutyric acid is widely utilized as an effective ethylene biosynthesis inhibitor and functional intermediate to engineer novel crop protection agents and post-harvest shelf-life extension formulations.